منابع مشابه
[Central precocious puberty].
Central precocious puberty, defined as the onset of puberty before the age 8 years in girls and 9 years in boys, results from a premature activation of gonadotropin-releasing hormone neurons in the hypothalamus. This condition is characterised by early pubertal changes, acceleration of growth velocity, and rapid bone maturation that often result in reduced adult height. It may be either idiopat...
متن کاملTreatment of Peripheral Precocious Puberty.
There are many etiologies of peripheral precocious puberty (PPP) with diverse manifestations resulting from exposure to androgens, estrogens, or both. The clinical presentation depends on the underlying process and may be acute or gradual. The primary goals of therapy are to halt pubertal development and restore sex steroids to prepubertal values. Attenuation of linear growth velocity and rate ...
متن کاملThe histrelin implant: a novel treatment for central precocious puberty.
OBJECTIVE Standard treatment of central precocious puberty (CPP) consists of intramuscular or subcutaneous administration of a gonadotropin-releasing hormone (GnRH) agonist (GnRHa) at 3- to 4-week intervals. Although generally effective in suppressing clinical and laboratory parameters of puberty, GnRHa injections are painful, and the need for monthly clinic visits may contribute to poor compli...
متن کاملCentral Precocious Puberty: Update on Diagnosis and Treatment.
Central precocious puberty (CPP) is characterized by the same biochemical and physical features as normally timed puberty but occurs at an abnormally early age. Most cases of CPP are seen in girls, in whom it is usually idiopathic. In contrast, ~50% of boys with CPP have an identifiable cause. The diagnosis of CPP relies on clinical, biochemical, and radiographic features. Untreated, CPP has th...
متن کاملCentral Precocious Puberty: Treatment with Triptorelin 11.25 mg
BACKGROUND Few data are available on quarterly 11.25 mg GnRH analog treatment in central precocious puberty (CPP). AIM To assess the efficacy of triptorelin 11.25 mg in children with CPP. PATIENTS 17 patients (16 females) with CPP (7.9 ± 0.9 years) were treated with triptorelin 11.25 mg/90 days. METHODS Gonadotropins, basal-, and GnRH-stimulated peak, gonadal steroids, and pubertal signs ...
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ژورنال
عنوان ژورنال: Journal of the Endocrine Society
سال: 2019
ISSN: 2472-1972
DOI: 10.1210/js.2019-00036